Cyclophosphamide - Endoxan

Cyclophosphamide is a prescribed anticancer drug to treat cancer in adults and childhood and deals with kidney problems in children.

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Category: Cyclophosphamide

Active substance: Cyclophosphamide

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Manufacturer: Zydus Healthcare Ltd

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Cyclophosphamide - Endoxan 50mg

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Usage

What is Cyclophosphamide?

Cyclophosphamide is a prescribed anticancer drug to treat cancer in adults and childhood and deals with kidney problems in children.

Drug may also use in combination with other anticancer drug.

Based on the treatment routine, cyclophosphamide can be consumed by mouth or injected into veins.

When using the medicine, patients must stay hydrated and prevent unwanted cause that makes the condition worse.

It comes under a group of cancer medicines known as an alkylating agent.

To manage the effects of cancer, patients don't use medicine themselves. Follow the doctor's prescription to prevent adverse effects.

Medicine is very useful in treating cancer and nephrotic syndrome and helps patients who suffer from a high risk of problems.

Using neosar is the best way to reduce the risk of cancer and other problems in children and adults.

Patients must continue taking the drugs as prescribed by the doctor.

Utilize it as an effective method to control cancer cell growth and prevent spreading.

Patients can visit Grant online Pharmacy to order medicine and follow physician instructions to take them.

How does Cyclophosphamide work?

Before using medicine, patients must consider the working mechanism of medicine and make the right decision to use it.

On the other hand, you must pay attention to how long does cyclophosphamide stay in your system and how it controls the cancerous effect.

Alkylating agent performs by damaging genetic material like DNA and RNA of cancer cells.

The main aim of this medicine is to impede the growth and multiplication of cancer cells in the body. The agent works in different forms.

It attaches the alkyl group to the DNA base and fragment by repairing the enzyme to restore the alkylated base.

It avoids DNA synthesis and RNA transcription from damaged DNA.

DNA damages through cross-link formation that avoids DNA separate for transcription or synthesis.

Medicine induces mispairing of nucleotides that go ahead to mutation.

Patients gain complete protection against cancerous cell growth and multiplication when taking medicine.

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How to use Cyclophosphamide?

This information gives general guidelines on the way this drug is usually taken. In some cases, individual recommendations may differ according to a particular condition.

Take Endoxan according to the prescription given to you by your oncologist or other specialist.
Usually, an oral dosage of cyclophosphamide is taken once daily. However, the frequency and dosage may vary.
Take the pill approximately at the same time each day; preferably in the morning if possible.
Consume enough liquids while taking the treatment and empty bladder frequently in order to decrease the risk of bladder and urogenital system's toxicity.
Take the pills in accordance with the prescribed dosage. Cyclophosphamide is a cytotoxic medication and needs special care during handling.
Make regular blood tests, since cyclophosphamide causes low levels of blood white cells, platelets, and red blood cells.
Contact your healthcare specialist immediately if you have fever, unusual bruises or bleeding, painful micturition, and presence of blood in urine.
Don't change dosage or quit the treatment without specialist's prescription and recommendations for further course of therapy.

This information is general and cannot substitute for professional medical guidance. Always follow the recommendations of your healthcare specialist.

Indications/Usage

Endoxan 50 mg consists of an alkylating agent called cyclophosphamide which is an anti-cancer drug. Oral cyclophosphamide can be taken on its own or together with other treatments for treating different forms of cancer like Hodgkin and non-Hodgkin lymphomas, mycosis fungoides, neuroblastoma, multiple myeloma, ovarian, retinoblastoma, and leukemia; also, breast cancer. It can be used in certain cases of children suffering from corticosteroid-resistant or corticosteroid-intolerant minimal change nephrotic syndrome.

Cyclophosphamide gets metabolized in the liver to active metabolites which interfere with division of cancerous cells and make cross-links, leading to damage of cancer cells' DNA. However, it damages other rapidly dividing healthy cells as well. Therefore, blood testing and close observation must be done.

Contact your doctor if your symptoms don't improve or worsen despite treatment with this medication.

Availability at Grant Pharmacy

Grant Pharmacy understands the critical need for access to effective cancer treatments and ensures the availability of cyclophosphamide for patients in the community.

Missed dose

Patients must follow dosing information when taking medicine. If you miss the cyclophosphamide dose accidently, you can take it very soon before the next schedule arrives.

If you are in the next dose schedule, you must prevent taking missed doses. Getting back to a regular schedule is essential to overcome the problems.

Don't take double doses that affect the body severely and enhance side effect risk.

Overdose

You must consult a doctor immediately if you take more than a prescription.

Overdose causes effects like

Loss of appetite
Nausea
vomiting

Precautions and warnings

Before using medicine, patients must inform their physician about the medicine used to treat certain medical conditions.

With it, physicians recommend medicine with an ideal dose that works smoothly in the body.

Patients must inform their doctor about their medical history when it comes to procytox treatment.

Kidney and urinary damage or injury
Low blood cell counts
Lung problems
Heart problems
Liver damage or injury

Patients must check their progress regularly to know their condition and when to stop or change the dose.

Patients never do any hard work that requires mental alertness.

After taking medicine, patients never do anything and just go to bed and sleep.

During treatment, patients must avoid drinking alcohol, which alters their working mechanism.

You can never drive a vehicle or operate heavy machines or equipment when feeling dizzy.

Doctors never recommend it to pregnant or breastfeeding women that affect little ones.

Proper caution is essential for pregnant and breastfeeding women.

Medicine also passes to breast milk that harms the baby.

Doctors consider everything in detail and recommend doses that suit the patient's requirements to treat the condition.

Side effects of Cyclophosphamide

Dyspepsia
Vomiting
Lack of appetite
Hair loss
Tiredness
Low number of white blood cells
Low numbers of platelets
Anemia
The risk of infections increases
Mucosa of the urinary tract is irritated and the presence of blood in urine

Severe complications include severe bone-marrow suppression, hemorrhagic cystitis, kidney's toxicity, heart or lungs' toxicity, infertility, and secondary cancers.

These side effects are mostly temporary and mild. If any side effect troubles you, contact your healthcare specialist.

Storage

Proper storage practice is essential to store cyclophosphamide injection properly and prevent unwanted access.

Patients must keep medicine in a closed container at ideal room temperature.

It is the best way to keep away medicine from moisture, heat, and direct sunlight.

Store medicine in the proper place, and reach by children and pets quickly.

Don't keep outdated medicine in place and dispose of them ideally.

Interactions

Medicine may interact with other drugs and supplements that change functions and enhance the risk of side effects.

You can never stop, start and modify the dose without consulting with a doctor.

Let doctors know about prescription and non-prescription drugs, herbal supplements and others to use for medical conditions.

Patients never take the below medicine along with this drug, like

Measles virus vaccine, live
Mumps virus vaccine, live
Rotavirus vaccine, live
Rubella virus vaccine, live
Varicella virus vaccine, live
Zoster vaccine, live

Patients must check the cost of cytoxan and purchase them at the Grant Pharmacy. Whether drugs are prescribed together, physicians may modify the dose and how often you take one or both drugs.

Cyclophosphamide undergoes metabolism in cytochrome P450 pathways; therefore, the drugs affecting this pathway affect exposure to its active metabolites. Drugs which may enhance or change the toxic effect of cyclophosphamide are protease inhibitors, anticonvulsants which are enzyme inducers, rifampicin, and other cytotoxic agents.

Drugs, which may increase the risks due to bone-marrow suppression, immunosuppressants, heart, kidneys, lung, and bladder toxicity, may increase risks of treatment. The immunization schedule has to be revised due to the immunosuppressive properties of cyclophosphamide.

Tell your healthcare specialist about all medications, herbs, and supplements you are using before beginning the treatment.

Frequently asked questions about Cyclophosphamide (FAQs)

When patient should visit the doctor during treatment?

Patients visit the doctor when experiencing issues like skin rash, mouth ulcer, persistent and extreme fatigue, painful urination, unusual bleeding, chest pain, and a lot more.

Is Cyclophosphamide works for non-cancer condition?

Cyclophosphamide is beneficial to treat non-cancer conditions like nephrotic syndrome. It is a good measure to control such problems in children. It is helpful for children who face intolerable side effects with other drugs. Proper caution is vital to avoid risk and treat conditions seamlessly.

How to reduce the risk of infection while taking Cyclophosphamide?

Patients can reduce the risk of infection during Cyclophosphamide by washing their hands properly. Patients must avoid crowded places and food-borne illnesses. Wash raw fruits and vegetables are crucial before eating and cooking. These are significant during treatment.

What are the expert guidelines to follow when taking such medicine?

Medicine is very useful in treating cancer. Experts advise patients to drink enough fluids and urine frequently to avoid urinary issues. Consult a physician regularly is better to know blood count.

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

DailyMed – Cyclophosphamide Tablets 25 mg and 50 mg, Baxter Healthcare
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=769ded74-6186-40a8-8e44-ceff67287451

FDA Prescribing Information – Cyclophosphamide Tablets for Oral Use
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012141s090%2C012142s112lbl.pdf

Electronic Medicines Compendium – Cyclophosphamide Tablets 50 mg Patient Information Leaflet, Baxter
https://www.medicines.org.uk/emc/files/pil.1813.pdf

MedlinePlus – Cyclophosphamide Drug Information
https://medlineplus.gov/druginfo/meds/a682080.html

Disclaimer: The medicine information provided on this page is for general knowledge purposes only. It is not intended to replace professional medical advice. Please consult your doctor or pharmacist before using any medicine.
- Grant Pharmacy

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