Macitentan (Opsutan)

Macitentan Tablets 10mg (Opsutan) is a prescription drug useful for treating pulmonary arterial hypertension or high Blood Pressure in the vessels.

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Category: Macitentan

Active substance: Macitentan

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Manufacturer: Cipla

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Macitentan (Opsutan) 10mg

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Usage

What Is Macitentan Tablets 10mg (Opsutan)?

Macitentan Tablets 10mg (Opsutan) is a prescription drug useful for treating pulmonary arterial hypertension or high Blood Pressure in the vessels.

These blood vessels carry the blood from the heart to the lungs.

These are significant options for helping to delay the disease progression and even improve quality of life.

The opsutan tablet is available with a combination of various medicines.

These medications need to be taken with or even without food.

Opsutan medicine needs to be used regularly to get full benefit.

Doctors would suggest the appropriate dosage for improving the symptoms.

Normally, opsutan 10 mg contains Macitentan, and this belongs to the Group of Medicines called the Endothelin Receptor Antagonists.

These medicines are used with many other medicines for treating pulmonary hypertension in adults.

It is a condition which occurs commonly due to the higher high blood pressure in the pulmonary arteries or blood vessels carrying the blood from the heart to the lungs.

Normally, the Macitentan Tablets 10mg (Opsutan) will not be given to patients who are allergic to the Macitentan or Soya.

The medication is also not prescribed for patients who have higher levels of Liver enzymes in the blood.

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How Does Macitentan Tablets 10mg (Opsutan) Work?

Macitentan Tablets 10mg is widely called as Endothelin Receptor Blocker. The medication works by blocking the action of endothelin.

The endothelin is a substance that causes the blood vessels carrying the blood to the lungs to get narrow or constrict.

Narrowing of the blood vessels would increase pressure in the blood vessels of the lungs.

Taking the macitentan helps the patient to relax blood vessels along with easily increasing the supply of blood for the lungs.

Pulmonary arterial hypertension or PAH can cause shortness of tiredness, dizziness, breath, swelling in ankles and legs and chest pain.

Pulmonary arterial hypertension can be caused by thickening of the walls of arteries.

The arteries supply the lungs with the blood, so the PAH causes the blood vessels to narrow. Taking the macitentan 10 mg helps to relax the blood vessels easily.

These are also helpful for lowering the blood pressure in the arteries of the lungs.

It is easier for the patients to carry out their daily activities more effectively and feel less dizzy.

The Macitentan Tablets 10mg (Opsutan) works with blocking the action of the endothelin hormone.

The endothelin hormone is a chemical causing vasoconstriction, and this leads to the relaxing and widening of the blood vessel walls.

It results in a reduced range of blood pressure in blood vessels.

Lowering blood pressure automatically can be useful for reducing dizziness and tiredness.

Macitentan Tablets 10mg is a spectacular option for treating pulmonary hypertension in the affected individuals.

Taking the exact dose is essential for getting the complete effect of the medicine to work in the body.

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How To Use Macitentan Tablets 10mg (Opsutan)?

The following information presents general characteristics of the administration of the drug. Individual recommendations may differ depending on the condition and therapy.

administer Macitentan once daily according to instructions of your healthcare provider
the drug is recommended to be taken with or without food as food does not change significantly the level of exposure to the drug
try to use the medication at approximately the same time everyday
continue using macitentan as advised even if your state is stable. Use of Macitentan should not be discontinued without consulting your healthcare provider
if you miss the dose, take it as soon as you remember and do not use additional dose to compensate the missed one
in females of reproductive age before the therapy it is necessary to conduct tests confirming non-pregnant condition and to use effective methods of birth control before the beginning of therapy, during its whole course and for a month after the termination of macitentan therapy
before the therapy and during it it is necessary to conduct determination of hepatic enzymes as there is a possibility of liver injury when using endothelin receptor antagonists
it is also necessary to determine hemoglobin concentration before therapy and periodically during it since macitentan decreases hemoglobin levels
information about appearance of unusual weight gain or swelling of ankles and feet is essential during macitentan therapy since fluid retention may occur during therapy with macitentan.

It should be noted that the above information is provided in a general form and cannot substitute individual instructions provided by your healthcare provider.

Usage / Indications

Macitentan (Opsutan) is a medication which contains the active substance macitentan - endothelin receptor antagonist intended for treatment of pulmonary arterial hypertension (PAH, WHO group 1) in adults. The disease is characterized by development of high blood pressure in blood vessels conducting blood from the heart to the lungs. Macitentan is used for reduction of risk of disease progression and hospitalization due to PAH.

Macitentan reduces the effects of endothelin-1 by blockage of receptors ETAs and ETB which participate in development of pulmonary vasoconstriction and abnormalities of structure of blood vessels. This effect allows reducing of pulmonary vascular resistance and improve blood circulation in lungs.

Macitentan requires special caution regarding embryo-fetal toxicity and cannot be used in pregnancy.

If the symptomatology is not relieved or does not show expected improvement consult your doctor.

Missed Dose:

Whether you have missed a dose of Macitentan Tablets 10mg then you need to take the medicine as soon as you remember it.

When it is almost time for the next dosage then you can skip the missed dose and continue with the regular schedule. Do not double-dose the Opsutan medicine, as it could lead to serious side effects.

Overdose:

Whether you or anyone else have taken more amounts of the Macitentan Tablets 10mg accidentally, then it is important to consult a doctor immediately. Overdosing could cause some side effects, such as headache, nausea, vomiting and many others.

Usual Dosage

Dosage depends on the patient’s condition, age, weight, organ function and the effects of therapy.

In official prescribing information of the drug in common cases it is recommended: in case of pulmonary arterial hypertension in adult patients the recommended dose of macitentan is 10 mg orally once daily. Administration of macitentan more frequently than once daily and doses more than 10 mg per day were not thoroughly studied in patients with PAH and are not recommended.

In the current prescribing information of the drug in USA there is no specific regimen of titration in the beginning and further during maintenance therapy; 10 mg once daily is the recommended dose of therapy and maximal dosage.

Your doctor will define the most adequate dose and regimen of therapy.

Precautions And Warnings:

Pregnancy:

Macitentan Tablets 10mg (Opsutan) are not recommended for use by women during pregnancy or planning for pregnancy.

Women of childbearing potential must use contraceptive measures. Consult the doctor to get the prescription if accidental pregnancy occurs when taking the medicine.

Breastfeeding:

Normally, the Macitentan Tablets 10mg is not recommended for use in breastfeeding women. These could be causing the side effects on the child as the medicine could pass through the breast milk. Immediately consult the doctor before taking the opsutan tablet.

Driving And Using Machines:

Doctors recommend not operating machines or driving when you are taking the macitentan tablets 10 mg (Opsutan).

Some patients could feel the headache or even low blood pressure when taking the medication.

Liver:

Doctors do not recommend the Doctors Macitentan Tablets 10mg (Opsutan) for patients with liver diseases. These are also not prescribed for patients who are tested with higher levels of Liver enzymes in the blood. Please consult the doctor before taking the medication for pulmonary arterial hypertension.

Kidney:

Patients with kidney problems must take the Macitentan Tablets 10mg (Opsutan) with extreme caution. Please consult the doctor before taking the medication.

Allergy:

Whether you are allergic to the Macitentan, soya, or even other ingredients used in this medicine, then it is better to avoid taking the medicine.

Lungs:

Macitentan Tablets 10mg (Opsutan) need to be taken with extreme caution when you have a history of lung diseases like Pulmonary Veno-Occlusive Disease or Obstruction of the lung vein. Please consult your doctor before taking the Macitentan Tablets 10mg.

Use In Pediatrics:

Opsutan Tablets are not recommended for usage in adolescents or children. Please consult the doctor before taking the Opsutan tablet for pulmonary arterial hypertension.

While taking the Macitentan Tablets 10mg (Opsutan), it is essential to take certain precautions and warnings.

Maintain your diet with vegetables, fruits, omega-3-rich foods, lean protein sources, whole grains, legumes and many more.

Keep the body weights under control using a BMI of 19.5 to 24.9.

Include heart-healthy omega-3 fatty acids-enabled food in the diet.

Use lower-fat cooking oil such as soybean oil, coconut oil, canola oil, and olive oil. These would be automatically lowering the elevated blood pressure.

It is best to avoid taking chronic stress as these could raise blood pressure.

Spend more time with loved ones, and you need to practice mindfulness techniques.

Do not consume salt more than 2,300 mg each day in the food.

Avoid taking the alcohol or smoking. Save more money on the purchase with the lowest macitentan price online via Grant Pharmacy

Patient Support Programs:

Grant Pharmacy provides comprehensive patient support programs, offering assistance with medication management and access to resources.

Side Effects Of Macitentan Tablets 10mg (Opsutan):

Among the common side effects of Macitentan (Opsutan) may be noted:

anemia
stuffy nose or sore throat
bronchitis
headache
influenza
urinary tract infection

These side effects usually disappear soon. In case of persistent or unbearable manifestations consult your doctor.

Storage:

Store Macitentan Tablets 10mg in a cool and dry place

Keep the medicine away from sunlight

Global Accessibility:

Grant Pharmacy offers worldwide shipping, making Macitentan Tablets 10mg accessible to individuals seeking effective PAH treatment globally.

Interactions:

Drug-Drug Interactions:

Macitentan Tablets 10mg (Opsutan) medicine can interact with certain drugs, which could cause side effects. Below are some of the drug interactions with Opsutan listed

Antibiotics - Telithromycin, Ciprofloxacin, Erythromycin, Rifampicin, Clarithromycin
Medicine to treat epilepsy and depression - Carbamazepine
Medicines to treat depression - Nefazodone
Medicines to treat HIV infections - Ritonavir, Saquinavir
Medicines to treat seizures - Phenytoin
Herbal Medicines to treat depression - St. John’s Wort
Medicines to treat and prevent organ rejection after transplant - Cyclosporine

Drug-Food Interaction:

Avoid consuming Alcohol as it can increase the side effects of the Opsutan Tablet

Avoid taking Piperine when using Macitentan Tablets 10mg

Drug Interaction

Strong CYP3A4 inducers (rifampin, etc.) may considerably decrease the level of macitentan and reduce its activity. It is recommended not to combine strong enzyme inducers and macitentan. Other strong enzyme inducers may produce the same effects.

Strong inhibitors of CYP3A4 enzymes (ketoconazole, ritonavir and others) may increase the level of macitentan and increase risks of undesirable effects. The combinations of such drugs and macitentan should be avoided according to official prescribing information of the drug in USA.

Concomitant use of medicines inhibiting simultaneously both CYP3A4 and CYP2C9 enzymes may lead to considerable increasing of macitentan level. Such drugs as fluconazole and amiodarone are examples of them. Concurrent use of moderate inhibitors of both enzyme systems or concurrent use of moderate inhibitors of CYP3A4 and CYP2C9 should be avoided.

Herbal medicine St. John's wort due to its enzyme inducing properties may reduce the levels of macitentan and needs discussion with healthcare provider.

Please, inform your doctor and pharmacist about all drugs, supplements and herbals you are taking before the therapy starts.

Frequently asked questions about Macitentan Tablets 10mg (Opsutan) (FAQs):

What Are Macitentan Tablets 10mg (Opsutan) Used For?

Macitentan Tablets 10mg (Opsutan) is used for treating pulmonary arterial hypertension, a condition that occurs due to high blood pressure in the pulmonary arteries.

How Macitentan Tablets 10mg Should Be Taken?

Take Macitentan Tablets 10mg as advised by a physician. You must Swallow the Tablet with a glass of water, and you must not crush or chew the medicine.

What Are The Common Side Effects Of Taking Macitentan Tablets?

Common side effects of taking Macitentan Tablets are anaemia, urinary tract infection, headache, and more. Consult a doctor when you are having the symptoms.

How Macitentan Tablets Works?

Macitentan Tablets work by blocking the action of Endothelin Hormone, which is a chemical causing vasoconstriction that leads to the relaxation of the blood vessel wall

Can Macitentan Tablets 10mg (Opsutan) Be Used In Pregnant Women?

No, the Macitentan Tablets 10mg is not recommended for pregnant women or breastfeeding. Women of childbearing potential need to use contraceptive measures for the medication.

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

FDA Prescribing Information – Opsumit (Macitentan), Revised April 2025
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/204410s031lbl.pdf

DailyMed – Opsumit (Macitentan) Tablets
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e484a50-55db-4b85-8c57-6cd1b0353abd

MedlinePlus – Macitentan
https://medlineplus.gov/druginfo/meds/a615033.html

European Medicines Agency – Opsumit (Macitentan) Product Information
https://www.ema.europa.eu/en/documents/product-information/opsumit-epar-product-information_en.pdf

Disclaimer: The medicine information provided on this page is for general knowledge purposes only. It is not intended to replace professional medical advice. Please consult your doctor or pharmacist before using any medicine.
- Grant Pharmacy

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