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Cyclophosphamide (Injection)

Cyclophosphamide (Injection)

Cyclophosphamide is a prescribed anticancer drug to treat cancer in adults and childhood and deals with kidney problems in children.
Alternative Search: Injection
Category: Cyclophosphamide
Active substance: Cyclophosphamide
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Manufacturer: Generic
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Cyclophosphamide (Injection) 1000mg

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2 Vials
$78.30 $39.15
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$150.60 $37.65
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8 Vials
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$415.80 $34.65
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Cyclophosphamide (Injection) 500mg

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$66.00 $33.00
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$342.00 $28.50
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Cyclophosphamide (Injection) 200mg

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$43.50 $21.75
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$87.00 $21.75
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8 Vials
$162.00 $20.25
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Usage

What is Cyclophosphamide?

Cyclophosphamide is a prescribed anticancer drug to treat cancer in adults and childhood and deals with kidney problems in children.

Drug may also use in combination with other anticancer drug.

Based on the treatment routine, cyclophosphamide can be consumed by mouth or injected into veins.

When using the medicine, patients must stay hydrated and prevent unwanted cause that makes the condition worse.

It comes under a group of cancer medicines known as an alkylating agent.

To manage the effects of cancer, patients don't use medicine themselves. Follow the doctor's prescription to prevent adverse effects.

Medicine is very useful in treating cancer and nephrotic syndrome and helps patients who suffer from a high risk of problems.

Using neosar is the best way to reduce the risk of cancer and other problems in children and adults.

Patients must continue taking the drugs as prescribed by the doctor.

Utilize it as an effective method to control cancer cell growth and prevent spreading.

Patients can visit Grant online Pharmacy to order medicine and follow physician instructions to take them. 

cycloxan

How does Cyclophosphamide work?

Before using medicine, patients must consider the working mechanism of medicine and make the right decision to use it.

On the other hand, you must pay attention to how long does cyclophosphamide stay in your system and how it controls the cancerous effect.

Alkylating agent performs by damaging genetic material like DNA and RNA of cancer cells.

The main aim of this medicine is to impede the growth and multiplication of cancer cells in the body. The agent works in different forms.

It attaches the alkyl group to the DNA base and fragment by repairing the enzyme to restore the alkylated base.

It avoids DNA synthesis and RNA transcription from damaged DNA.

DNA damages through cross-link formation that avoids DNA separate for transcription or synthesis.

Medicine induces mispairing of nucleotides that go ahead to mutation.

Patients gain complete protection against cancerous cell growth and multiplication when taking medicine. 

cyphos

How to use Cyclophosphamide?

Below is general information about how to take the medicine. Exact instructions may vary depending on your condition and treatment program.

  • The preparation of Cyclophosphamide injection should be performed by health care professionals only.
  • The 1000 mg presentation of Baxter includes 1,000 mg in 5 mL, which equals 200 mg/mL, and needs to be diluted before use intravenously.
  • The dosage and infusion schedule depend on type of cancer, treatment schedule, body weight or body-surface area, laboratory test results, other medications, etc.
  • Patient should stay well hydrated during or after treatment to facilitate urination and decrease risks of toxicity for the bladder and urinary tract.
  • According to official labeling, it is recommended to administer the medicine in the morning whenever possible allowing adequate hydration and more frequent urination during the day.
  • Blood test is needed periodically as the drug may cause bone marrow suppression including decrease of white blood cells, platelets, and red blood cells counts.
  • Notify your health care provider immediately if you have fever, symptoms of infections, bleeding problems, painful urination, blood in urine.
  • No additional doses should be given and delayed if needed by your oncology team based on the laboratory test results and your adverse reactions.
  • This medicine may cause harm to fetus, so the patient should discuss issues of pregnancy and contraception before treatment.

The information above is general and not intended to replace professional advice of your health care provider.

Indications / Usage

Cyclophosphamide injection 1000 mg from Baxter is an alkylating antineoplastic drug available in injectable form. It is used alone or in combination with other antineoplastics in various malignancies including Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma, certain leukemia, mycosis fungoides, neuroblastoma, retinoblastoma, ovarian carcinoma, and breast carcinoma.

This drug undergoes transformation in the liver to active metabolites interfering with DNA of rapidly dividing cells. Mechanism of antitumor action includes the formation of cross-links of tumor cell DNA which blocks proliferation and reproduction of the cells.

Contact your doctor if your symptoms do not get better with using the medication.

Availability at Grant Pharmacy

Grant Pharmacy understands the critical need for access to effective cancer treatments and ensures the availability of cyclophosphamide for patients in the community.

Missed dose

Patients must follow dosing information when taking medicine. If you miss the cyclophosphamide dose accidently, you can take it very soon before the next schedule arrives.

If you are in the next dose schedule, you must prevent taking missed doses. Getting back to a regular schedule is essential to overcome the problems.

Don't take double doses that affect the body severely and enhance side effect risk.

cycloxan

Overdose

You must consult a doctor immediately if you take more than a prescription.

Overdose causes effects like

  • Loss of appetite
  • Nausea
  • vomiting

Usual Dosage

Dosage varies depending on the condition, age, weight, organ function, and efficacy of treatment.

According to official prescription information, when Cyclophosphamide injection is used as the only antineoplastic agent in patients without hematologic deficiency, an initial intravenous course may be 40-50 mg/kg divided over 2-5 days. Other labeled intravenous regimens include 10-15 mg/kg every 7 to 10 days or 3-5 mg/kg twice weekly.

Nowadays in oncology practice, cyclophosphamide is often combined with other medicines in chemotherapy treatment programs, and so the actual dose and schedule of treatment may differ considerably from these general regimens. Dose adjustment or treatment delay may be required due to decreased blood cell counts, organ dysfunction, toxicity, and co-administration with other chemotherapeutic agents.

1000 mg is package strength, but not standard dose of single patient. Patient-specific dose should be calculated by treating oncology team.

Your doctor will determine the optimal dose and treatment regimen for you.

Precautions and warnings

Before using medicine, patients must inform their physician about the medicine used to treat certain medical conditions.

With it, physicians recommend medicine with an ideal dose that works smoothly in the body.

Patients must inform their doctor about their medical history when it comes to procytox treatment.

  • Kidney and urinary damage or injury
  • Low blood cell counts
  • Lung problems
  • Heart problems
  • Liver damage or injury

Patients must check their progress regularly to know their condition and when to stop or change the dose.

Patients never do any hard work that requires mental alertness.

After taking medicine, patients never do anything and just go to bed and sleep.

During treatment, patients must avoid drinking alcohol, which alters their working mechanism.

You can never drive a vehicle or operate heavy machines or equipment when feeling dizzy.

Doctors never recommend it to pregnant or breastfeeding women that affect little ones.

Proper caution is essential for pregnant and breastfeeding women.

Medicine also passes to breast milk that harms the baby.

Doctors consider everything in detail and recommend doses that suit the patient's requirements to treat the condition.

neophos

Side effects of Cyclophosphamide

Common or clinically significant side effects of cyclophosphamide may include:

  • Nausea
  • Vomiting
  • Loss of appetite
  • Hair loss
  • Exhaustion
  • Decreased counts of white blood cells
  • Decreased counts of platelets
  • Anemia
  • Increased risk of infections
  • Bladder irritation or blood in urine

These side effects are usually transient and not severe. Contact your doctor if any side effect becomes troublesome or persistent.


phoxelon

Storage

Proper storage practice is essential to store cyclophosphamide injection properly and prevent unwanted access.

Patients must keep medicine in a closed container at ideal room temperature.

It is the best way to keep away medicine from moisture, heat, and direct sunlight.

Store medicine in the proper place, and reach by children and pets quickly.

Don't keep outdated medicine in place and dispose of them ideally.

ctx-gls 500

Interactions

Medicine may interact with other drugs and supplements that change functions and enhance the risk of side effects.

You can never stop, start and modify the dose without consulting with a doctor. 

Let doctors know about prescription and non-prescription drugs, herbal supplements and others to use for medical conditions.

Patients never take the below medicine along with this drug, like

  • Measles virus vaccine, live
  • Mumps virus vaccine, live
  • Rotavirus vaccine, live
  • Rubella virus vaccine, live
  • Varicella virus vaccine, live
  • Zoster vaccine, live

Patients must check the cost of cytoxan and purchase them at the Grant Pharmacy. Whether drugs are prescribed together, physicians may modify the dose and how often you take one or both drugs.

  • Abametapir
  • Atazanavir
  • Boceprevir
  • Ceritinib
  • Adenovirus vaccine
  • Amprenavir
  • Carbamazepine
  • Darunavir
  • Fosamprenavir
  • Cobicistat
  • Cyclosporine
  • Eslicarbazepine Acetate
  • Fosphenytoin
  • Doxorubicin
  • Doxorubicin hydrochloride liposome
  • Etanercept

Taking these medicines causes enhanced side effects. Patients must follow the dose correctly and prevent side effects.

Grant Pharmacy is dedicated to supporting individuals affected by cancer and providing access to quality medications like cyclophosphamide to help them in their fight against the disease.

Drug Interactions

Cyclophosphamide is metabolized in the liver with participation of several cytochrome P450 enzymes including CYP2B6, CYP3A4, CYP2C9, CYP2C19, and others. Drugs strongly inducing or inhibiting these enzymes may affect activation or clearance of cyclophosphamide and potentially change its efficacy and toxicity.

Other myelosuppressive or cytotoxic drugs may increase risks of low blood cell counts and infections caused by cyclophosphamide. Drugs causing heart, kidney, liver, or bladder injury may increase overlapping toxicities and require additional monitoring.

As cyclophosphamide causes strong immunosuppression, vaccination schedule, especially with live vaccines, should be checked by treating oncology team before vaccination.

Discuss with your doctor and pharmacist all drugs, supplements, and herbal products you are taking prior to treatment.

Frequently asked questions about Cyclophosphamide (FAQs)

When patient should visit the doctor during treatment?

Patients visit the doctor when experiencing issues like skin rash, mouth ulcer, persistent and extreme fatigue, painful urination, unusual bleeding, chest pain, and a lot more. 

Is Cyclophosphamide works for non-cancer condition?

Cyclophosphamide is beneficial to treat non-cancer conditions like nephrotic syndrome. It is a good measure to control such problems in children. It is helpful for children who face intolerable side effects with other drugs. Proper caution is vital to avoid risk and treat conditions seamlessly.

How to reduce the risk of infection while taking Cyclophosphamide?

Patients can reduce the risk of infection during Cyclophosphamide by washing their hands properly. Patients must avoid crowded places and food-borne illnesses. Wash raw fruits and vegetables are crucial before eating and cooking. These are significant during treatment.

What are the expert guidelines to follow when taking such medicine?

Medicine is very useful in treating cancer. Experts advise patients to drink enough fluids and urine frequently to avoid urinary issues. Consult a physician regularly is better to know blood count.

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

DailyMed – Baxter Cyclophosphamide Injection 500 mg/2.5 mL and 1000 mg/5 mL
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=34dbffee-80e0-49c3-90e8-95713a0b7fbe

MedlinePlus – Cyclophosphamide Injection
https://medlineplus.gov/druginfo/meds/a611044.html

FDA Prescribing Information – Cyclophosphamide Injection
https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/217651Orig1s000Correctedlbl.pdf

Disclaimer: The medicine information provided on this page is for general knowledge purposes only. It is not intended to replace professional medical advice. Please consult your doctor or pharmacist before using any medicine.
- Grant Pharmacy

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