Tofacitinib (Tofajak)

Tofajak 5 mg tablet contains Tofacitinib as an active ingredient. It is used for the treatment of rheumatoid arthritis and psoriatic arthritis.

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Category: Tofacitinib

Active substance: Tofacitinib

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Manufacturer: Cipla

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Tofacitinib (Tofajak) 5mg

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Usage

Tofacitinib 5mg (Tofajak)

Tofajak 5 mg tablet contains Tofacitinib as an active ingredient. It is used for the treatment of rheumatoid arthritis and psoriatic arthritis.

It aids to reduction pain, sensitivity and swelling in the joins by decreasing inflammation.

In addition, it may also help to slow down the progression of bone and joint damage.

It is the tablet prescribed by itself or else combination with any other medicine.

Thus, Tofajak is prescribed medicine that is suggested by doctors depending upon various factors such as age, weight, and seriousness of the issues.

Where to buy tofacitinib? Our Grant Pharmacy provides online deliveries. You can order your medicine through Grant Pharmacy website.

When it comes to buying on the online platform, it will be helpful to buy with the proper doctor's prescription from Grant Pharmacy.

Also, tofajak 5mg price is affordable to buy for everyone. So, buy it in reputable online stores and then gain more benefits.

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How does Tofacitinib 5mg (Tofajak) work?

Of course, the Tofajak 5 mg tablet is a Janus Kinase inhibitor that can work by blocking the action of the enzyme.

How does tofacitinib work? First, it will lessen the immune system activity and the inflammation that is connected with rheumatic diseases and ulcerative colitis.

It will inhibit the body from responding to these substances, which are referred to as cytokines. It can easily manage the growth and activity of the immune system cells and the blood cells.

Also, it inhibits the inflammation process in a fresh way that includes Janus Kinases.

tofacitinib 5 mg, tofacitinib uses,

How do you use Tofacitinib 5mg (Tofajak)?

In this section, there are provided general instructions for this medicine. However, there are differences among individual patients in terms of usage instruction depending upon the patient’s health problem and the treatment program.

Take Tofajak as per your healthcare practitioner’s prescription.
When administering this medicine orally, take it with or without food.
Consume Tofajak on fixed time.
Do not increase or decrease its amount without consulting your healthcare practitioner.
Prior to commencing this therapy, it is essential to conduct tuberculosis test and check other infections. There may be needed some tests for blood-cell count, liver and viral hepatitis.
Avoid the use of live vaccinations while on this medication unless your healthcare provider tells you differently.
Call your healthcare practitioner if you get symptoms like fever, chronic cough, shingles, unexplained weight loss, chest pain, trouble in breathing or pain and swelling in legs.
Blood tests may be needed to check blood-cell counts, liver enzymes and cholesterol level.

All the above-provided information is in general form only and does not substitute the information provided by your healthcare practitioner.

Indication/ Usage

This drug is a Janus kinase (JAK) inhibitor in tablet form that treats some forms of chronic inflammatory disease and autoimmune disorders. Tofajak (tofacitinib) is indicated for the treatment of adults having moderate to severe rheumatoid arthritis, active psoriatic arthritis, active ankylosing spondylitis, and moderate to severe ulcerative colitis who have already been given one treatment course without getting satisfactory response or who cannot tolerate their medications. For children with inflammatory arthritides, this treatment will be administered under specialist supervision.

The way in which tofacitinib functions includes blocking the JAK enzymes. It reduces the activity of immune system and inflammation causing joint pain, stiffness and swelling and intestine inflammation.

Consult your healthcare practitioner if your symptoms do not improve despite using this treatment or you continue experiencing them.

Missed Dose

It will assist you if you take the tofajak 5 mg tablet at the correct time, a good way to without problems deal with the disorder.

If you miss the pill, take it as quickly as possible. If it is time for the next dosage, then omit the missed dose and then follow your regular timetable.

You have to usually observe the suitable time to take the tablet; in any other case, you may experience a few unfavourable side effects.

Overdose

In case you observe too much dosage taken, then you must take on-the-spot medicine through accomplishing the doctor or by way of their sure guidelines.

Overdosage of tofajak 5mg could have viable effects on the sufferers.

Usual Dosage

The dose varies due to patient’s health condition, age, weight, organ function and responsiveness to treatment.

Generally, the dose of immediate-release tofacitinib for adult having rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis is 5 mg twice daily. However, larger doses of tofacitinib are not suggested as it increases the safety concerns in these situations.

For treating ulcereative colitis in adult, the initial dose is generally given in the form of 10 mg twice daily for at least 8 weeks, after evaluating the patient’s response to this medication. Maintenance therapy will require dose of 5 mg twice daily. Larger exposure is not recommended for this therapy except in certain cases.

Dose modification in case of moderate or severe renal impairment, moderate hepatic impairment and concurrent use of certain strong enzyme inhibitors may be needed. This drug is not recommended in severe hepatic impairment.

Your healthcare provider is the one who decides the best dose for your health condition.

Precaution and Warning

Before buy tofacitinib, there are several precautions and warnings to think about:

Tofacitinib may additionally growth the danger of great infections, inclusive of bacterial, viral, fungal, or tuberculosis (TB) infections.

Earlier than beginning treatment, your healthcare issuer will determine your risk factors for infections and can endorse trying out for TB.

Report any signs of infection, which include fever, chills, cough, or persistent sore throat, to your medical doctor promptly.

There can be an accelerated risk of sure cancers, which include lymphoma and skin cancers, at the same time as taking Tofacitinib.

Your physician may also carry out regular skin assessments and display for signs of most cancers during treatment.

The tofajak cipla may motivate changes in blood mobile counts, such as decreases in white blood cells, crimson blood cells, and platelets.

Your physician may additionally perform liver feature exams before and at some stage in remedy to monitor for liver issues.

Uncommon cases of gastrointestinal perforations had been reported in people taking Tofacitinib.

Notify your health practitioner straight away if you experience intense abdominal pain, chronic vomiting, or blood in your stool.

Tofacitinib may additionally growth the risk of cardiovascular events, inclusive of heart attack, stroke, or blood clots inside the lungs.

Inform your doctor if you have a history of cardiovascular disorder or risk elements such as high blood strain, diabetes, or smoking.

Tofacitinib may additionally damage an unborn toddler if taken throughout pregnancy.

It is imperative to apply effective contraception at the same time as taking Tofacitinib and discuss your family planning with your doctor.

It isn't acknowledged if Tofacitinib passes into breast milk, so breastfeeding whilst taking this medication is not always advocated.

Keep away from stay vaccines whilst taking Tofacitinib, as the drugs may additionally interfere with the effectiveness of the vaccine.

Always talk about your medical records and any concerns with your healthcare provider earlier than starting Tofacitinib.

Comply with their recommendations intently and report any side effects or worsening signs directly.

Cost and Availability

At Grant Pharmacy, we understand the importance of providing accurate information regarding the cost and availability of medications like Tofacitinib 5mg (Tofajak). However, specific pricing and availability may vary based on factors such as location, supplier pricing, and insurance coverage.

Our Commitment:

At Grant Pharmacy, we are dedicated to fostering a supportive and caring environment where patients feel valued and empowered to prioritize their health. Our compassionate staff is here to listen to your concerns, answer your questions, and provide guidance on managing your health conditions effectively.

Side effects of Tofacitinib 5mg (Tofajak)

Infections of upper respiratory tract
Headache
Diarrhea
Nasopharyngitis
Nausea
Increased blood cholesterol
Increased liver enzyme levels
High blood pressure
Herpes zoster
Mild acne

Boxed Warning

Serious infections, death, malignancies, heart attacks, strokes, and thrombosis can be dangerous for patients taking Tofacinix (tofacitinib). Patients who are old with cardiovascular disease risk factors or are a cigarette smoker should take extra precautions against these side effects.

All of these side effects are generally mild and temporary in nature. Inform your healthcare provider if you experience these side effects for long period.

Storage

The tofacitinib tablets need to be stored at average temperatures.

It needs to be stored away from direct daylight.

You have to keep the Tofajak 5 mg pill in its packaging and place it out of infants.

You’ve got effectively discarded the pill whilst it is not always used.

Interaction

The tofacitinib dose may additionally interact with other medications, doubtlessly affecting their effectiveness or increasing the chance of facet results.

A few medications which can interact with Tofacitinib include stay vaccines, immunosuppressant’s, biologic agents, and certain antiviral medicines.

Moreover, tofacitinib tablets that affect liver enzymes, which include rifampin or ketoconazole, may additionally engage with Tofacitinib.

It is crucial to inform your healthcare company approximately all medicinal drugs, dietary supplements, and herbal products you are taking before starting Tofacitinib to limit the risk of interactions.

Your medical doctor can assist in manipulating capability interactions and regulating your remedy layout for this reason.

Drug Interaction

The metabolic activity of this medicine takes place mainly via CYP3A4 enzymes and minor part through CYP2C19. Some strong CYP3A4 inhibitors including ketoconazole can elevate the exposure of this drug. In addition to that, combination of moderate CYP3A4 inhibitor along with a strong CYP2C19 inhibitor, such as fluconazole, can increase the exposure. Combination of tofacitinib with certain strong CYP3A4 inducer like rifampicin can result in decreased concentration of it.

Combination with biological DMARDs, other JAK inhibitors or potent immunosuppressive medicines like azathioprine and cyclosporine can increase the chances of severe infections because it can cause immunosuppresion. Consult your healthcare provider before using other medication along with it.

(FAQ) Frequently Asked Question for Tofacitinib 5mg (Tofajak)

What is Tofacitinib, and what conditions does it treat?

Tofacitinib is a medicine classified as a Janus kinase (JAK) inhibitor used to deal with autoimmune illnesses inclusive of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

What’s the endorsed dosage of Tofacitinib?

The recommended dosage of Tofacitinib may additionally vary depending on the situation being dealt with and person patient’s elements. For adults with rheumatoid arthritis, the everyday starting dose is 5mg taken orally twice daily. Dosages might also differ for psoriatic arthritis and ulcerative colitis.

Are there any precautions or warnings associated with Tofacitinib?

Yes, Tofacitinib consists of numerous precautions and warnings, consisting of an increased chance of infections, cancer, blood issues, liver troubles, gastrointestinal perforations, cardiovascular occasions, and interactions with different medicinal drugs.

Can I able to take Tofacitinib if I am pregnant or breastfeeding?

Tofacitinib might also harm an unborn infant if taken at some stage in pregnancy and isn't encouraged during breastfeeding. It is essential to discuss own family making plans and use powerful contraception even as taking Tofacitinib.

How long does it take for Tofacitinib to begin working?

The onset of action of Tofacitinib may also vary from individual to individual. A few individuals can also begin to revel in symptom relief within a few weeks of beginning treatment, at the same time as others may additionally require extra time.

What are the common side effects of Tofacitinib?

Common side effects of Tofacitinib may additionally encompass infections, headache, Diarrhea, nausea, stomach pain, increased blood strain, liver enzyme abnormalities, expanded cholesterol levels, top respiration tract infections, and rash.

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

FDA Prescribing Information – Xeljanz/Xeljanz XR (Tofacitinib), Revised March 2026
https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/203214s041lbl.pdf

DailyMed – Tofacitinib Tablets, Updated May 2026
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7d4f5cfa-35a8-1458-a609-f6b417946abb

Pfizer India – Xeljanz (Tofacitinib) Prescribing Information
https://labeling.pfizer.com/ShowLabeling.aspx?id=15018

MedlinePlus – Tofacitinib Drug Information
https://medlineplus.gov/druginfo/meds/a613025.html

Disclaimer: The medicine information provided on this page is for general knowledge purposes only. It is not intended to replace professional medical advice. Please consult your doctor or pharmacist before using any medicine.
- Grant Pharmacy

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