Pirfenidone (Pirfenex)

Pirfenidone 200mg (Pirfenex) is useful for treating Idiopathic Pulmonary Fibrosis (IPF), a lung disease.

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Category: Pirfenidone (Pirfenex)

Active substance: Pirfenidone (Pirfenex)

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Manufacturer: Cipla

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Pirfenidone (Pirfenex) 200mg

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Usage

What Is Pirfenidone 200mg (Pirfenex)?

Pirfenidone 200mg (Pirfenex) is useful for treating Idiopathic Pulmonary Fibrosis (IPF), a lung disease.

Pirfenex 200 mg Tablet involves active ingredients called Pirfenidone. Pirfenex 200 mg Tablet is only used on adults and must be taken with a prescription from a doctor.

At Grant Pharmacy, we prioritize offering effective medications to our customers, and Pirfenidone 200mg, commonly known as Pirfenex, is no exception.

Normally, pirfenex is an effective medicine for treating the lung disease called IPF.

These are not recommended for patients having the end stage of the kidney or liver diseases.

The pirfenidone is not recommended for patients who are below 18 years of age.

Pirfenidone 200mg (Pirfenex) is normally the prescription medicine which is used for treating idiopathic pulmonary fibrosis.

These would automatically reduce the scarring and swelling in the lungs. These are also helpful for breathing better.

Consult the doctor before taking the Pirfenidone 200mg (Pirfenex) before taking the medicine for the dosage.

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How Does Pirfenidone 200mg (Pirfenex) Work?

Pirfenidone 200mg (Pirfenex) is an Antifibrotic medication which works by blocking the action of the natural substances causing fibrosis in our body.

Normally, it will easily reduce scarring and swelling in the lungs. These would make breathing a completely efficient option.

Pirfenidone 200mg (Pirfenex) works by easily decreasing the production of the Extracellular Matrix (ECM) proteins.

The ECM plays a major role in contributing to the growth of fibrosis and even hardening lung tissue.

Before taking the medication, it is essential to know how does pirfenidone work.

Pirfenidone 200mg (Pirfenex) works with easily slowing the progression of the lung disease.

These would automatically improve lung function in a fantastic manner.

Idiopathic pulmonary fibrosis is a lung disease which is caused by the thickening and stiffening of lung tissue. These also eventually form scar tissue in the lungs.

Fibrosis could result from various cycles of damage to the lungs, so it is essential to treat it immediately.

Normally, various metabolites are detected after the oral administration of pirfenidone.

The pathways also involve CYP1A2-mediated 5-hydroxylation along with subsequent oxidation for creating the 5-carboxy pirfenidone.

Pirfenidone, along with 5-carboxy pirfenidone, will vary with plasma quantities.

The pirfenex 200mg is involved with the Pirfenidone, and these belong to the group of medicines called the Anti-inflammatory agents or Anti-fibrotics.

Anti-fibrotics or Anti-inflammatory agents are suitable for treating mild to moderate Idiopathic pulmonary fibrosis in adults.

Idiopathic Pulmonary Fibrosis is a condition which causes the tissues in the lungs or alveoli to become swollen or even scarred over time.

These would make breathing difficult and harder for the lungs to work properly.

Pirfenidone 200mg (Pirfenex) comes under the Synthetic Pyridone drugs, which act as an Antifibrotic Agent the anti-inflammatory and antioxidant properties.

These are widely useful for treating IPF, a chronic form of interstitial pneumonia.

Pirfenex 200mg works to regulate the Tumor Necrosis Factor (TNF) pathways.

It acts as a better option for modulating cellular oxidation in an effective manner.

The FDA approved Pirfenidone with Nintedanib as a drug to treat IPF.

Before buying the Pirfenidone 200mg (Pirfenex) medicine, you can click to learn about the Pirfenex price online from Grant Pharmacy.

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How to Use Pirfenidone 200mg (Pirfenex)?

This is the general information about using the drug. The way of using it may vary depending on your medical condition.

Take Pirfenex according to your doctor's recommendations.
Pirfenidone drug is usually prescribed three times a day when having meals. Intaking of the drug together with the food may decrease symptoms of nausea and dizziness.
Use the drug approximately at the same time during each day.
At first, the drug is taken in the low dose, but with passing days the dose of Pirfenex is increased to the recommended one during the period of 14 days.
Swallow capsules or tablets with some water.
Limit sun exposures as long as possible, since pirfenidone can cause photosensitivity. Apply appropriate means to protect your skin from exposure to ultraviolet light.
Avoid smoking cigarettes during the treatment, since smoking can interfere with the pirfenidone's metabolism and may weaken its action.
The tests of liver function are recommended before the beginning of treatment and from time to time during the therapy of pirfenidone as the drug can damage your liver.
According to the official prescribing information, if the treatment of pirfenidone is stopped for 14 days and longer, it is recommended to restart the whole process of pirfenidone dose increasing during 14 days.
Avoid the intake of two doses of the drug in case of the missed dose.

The information above is given to you generally. Do not consider it as a recommendation and take this drug following the instructions of your doctor only.

Usage/ Indication

Pirfenex drug consists of pirfenidone which is an antifibrotic belonging to pyridone class. Pirfenidone drug is employed for treatment of idiopathic pulmonary fibrosis (IPF). Idiopathic pulmonary fibrosis is a disease characterized by progressive accumulation of scar tissue in lungs. Pirfenidone can help in delaying deterioration of lung functions related to idiopathic pulmonary fibrosis.

The way how pirfenidone is working in IPF patients has not been clarified yet. The effects are assumed to be caused by antifibrotic and anti-inflammatory activities of the drug that decrease lung scarring process.

If the condition has not improved after the therapy or if the symptoms persist, inform your doctor about it.

Missed Dose:

Whether you have missed a dose of Pirfenidone 200mg then is essential to take the missed dose as soon as you remember it.

When it is time for the next dose, then, you need to skip the missed dose and continue with the regular schedule.

Take the pirfenidone dose at the exact time as prescribed by the doctor to get the maximum results.

When you have missed 14 days or more days in the treatment row then you need to restart the treatments prescribed by the doctor.

Overdose:

Do not overdose on taking Pirfenidone 200mg as it could lead to severe side effects in the body. Whether you have overdosed accidentally, then, it is essential to seek medical attention immediately.

Usual Dosage

The dosage of the medication depends on your condition, age, weight, body function, treatment response, etc.

The common dosage is gradually increased for the first 14 days: from the first till the seventh day, it is 267 mg of pirfenidone three times a day (total dose - 801 mg per day); from the eighth till the fourteenth day, it is 534 mg of pirfenidone three times a day (total dose – 1,602 mg per day); from the fifteenth day and longer, it is 801 mg of pirfenidone three times a day (total dose - 2,403 mg per day). All doses should be taken during the meal.

Sometimes, dose reductions or temporary interruptions of treatment may be required due to such side effects as significant gastrointestinal reactions, photosensitivity, rash, and elevation of liver enzymes. Pirfenidone is not indicated for patients with end-stage renal disease on dialysis.

Your doctor will establish an individual dosage and regime of treatment.

Precautions and Warnings:

Before taking Pirfenidone 200mg (Pirfenex), it is essential to know about the precautions and warnings issued by the doctors.

Normally, the pirfenex tablet must not be used when you are having the kidney or liver disorders.

Whether you are taking Fluvoxamine for treating obsessive-compulsive disorder or depression, then it is best to avoid taking pirfenidone 200mg (Pirfenex).

You need to use sunscreen daily and then cover your legs, hands and head to reduce exposure to sunlight.

Pregnancy:

Talk to your doctor whether you are pregnant or planning to get pregnant before taking the Pirfenidone 200mg (Pirfenex). The medicine is not prescribed for pregnant women as these could lead to potential side effects.

Breastfeeding:

Pirfenidone 200mg (Pirfenex) is not prescribed to Breastfeeding mothers as the medicine can pass into breast milk.

These could potentially harm the nursing infant. Please consult the doctor before taking the Pirfenidone 200mg.

Alcohol:

Do not consume alcohol while taking the Pirfenidone 200mg (Pirfenex) as it leads to side effects in the body.

Driving:

Pirfenidone 200mg (Pirfenex) could be decreasing the alertness. These can also affect vision, making you get dizziness and sleepy. You must not drive when these symptoms occur.

Kidney:

Pirfenidone 200mg is not recommended for patients who are having kidney disease and dialysis. Please consult the doctor to get alternative medicine for the treatment. Doctor could be altering the medicine for the treatments.

Liver:

Pirfenidone 200mg can be used with extreme caution on patients having liver disease. Consult the doctor to get the dose adjustments on the medicine.

Side Effects Of Pirfenidone 200mg (Pirfenex):

The common side effects of pirfenidone are:

Nausea
Rash
Gastrointestinal discomfort
Upper respiratory infection
Diarrhea
Fatigue
Headache
Indigestion
Dizziness
Vomiting
Difficulty in appetite
Photosensitivity reactions

They are usually temporary and weak. Contact your doctor in case you have serious side effect or in case it is persistent.

Storage:

Store the Pirfenidone 200mg (Pirfenex) in a cool and dry place.

Keep the medicine away from direct sunlight or moisture

Keep Pirfenidone 200mg away from children and pets.

Interactions:

Pirfenidone 200mg (Pirfenex) could interact with the other medicines. Talk with the doctor about the medicine that you are already taking or your health conditions.

Talk to the doctor whether you are taking any herbal preparations, supplements or medicines.

Know about the pirfenidone uses along with the interaction with other drugs before taking the medication.

Enoxacin
Ciprofloxacin (Antibiotic)
Propafenone (Used In Heart Problems)
Amiodarone
Fluvoxamine (used to treat your Mental Health)
Omeprazole (used in Indigestion)
Rifampicin (Antibiotic)

Pirfenidone 200mg (Pirfenex) can be taken with your meal to avoid stomach discomfort.

Check out the pirfenidone cost online from Grant Pharmacy before purchasing the medicine.

At Grant Pharmacy, we are committed to providing our customers with access to high-quality medications like Pirfenex to improve their health and well-being. Visit us today to learn more about Pirfenex and how it can benefit you or your loved ones.

Drug Interaction

Pirfenidone is metabolized mostly by the CYP1A2 enzyme. Powerful CYP1A2 inhibitors can strongly increase concentration of pirfenidone and its adverse effects. In general cases, fluvoxamine use is not recommended during the treatment with pirfenidone drug, while other CYP1A2 inhibitors, such as ciprofloxacin, require dose adjustment.

Strong inducers of CYP1A2 enzyme can lower concentrations of pirfenidone and reduce the effectiveness of the treatment. Cigarette smoking is able to stimulate CYP1A2 enzyme activity and lower concentrations of pirfenidone, therefore patients with IPF should not smoke cigarettes both before the treatment and during it.

Provide all information about the drugs you take to your doctor and pharmacist before the treatment.

Frequently Asked Questions about Pirfenidone 200mg (Pirfenex) (FAQs):

What Is The Monitoring Required While Taking Pirfenidone 200mg?

Normally, doctors will check on your Liver function before starting the Pirfenidone 200mg (Pirfenex). The tests would be repeated monthly for about 6 months. These will be done every 3 months to monitor lung function.

What Are The Side Effects Of Pirfenidone 200mg?

Some of the common side effects of taking Pirfenidone 200mg are nausea, tiredness, upset stomach, sensitivity to sunlight, diarrhoea, loss of appetite, and many more. Patients could also experience dry skin, skin rash, vomiting, bloating, and constipation.

Why Continue Treatment With Pirfenidone 200mg (Pirfenex)?

Control the progression of the disease by taking Pirfenidone 200mg. It is also essential to preserve lung function that cannot be restored. These are also highly recommended for continuing the treatment with Pirfenidone 200mg. Talk to a doctor before taking the medicine for Idiopathic Pulmonary Fibrosis.

Is Pirfenidone 200mg tablet a Steroid?

No, the Pirfenidone 200mg is not a steroid. These belong to the pyridines group of medicines for treating idiopathic pulmonary fibrosis (IPF). The medicine is only used on the adults having the idiopathic pulmonary fibrosis. Pirfenex helps reduce effects to make breathing better.

Is Pirfenidone 200mg Safer To Use during Pregnancy?

Pirfenidone 200mg is not recommended for use when you are pregnant or planning to become pregnant. The medicine could be causing potential risks for the unborn child. Please consult the doctor before taking Pirfenidone 200mg (Pirfenex) for the treatment.

Medically reviewed by the Grant Pharmacy Pharmacists Medical Team

Medical References

FDA Prescribing Information – Esbriet (Pirfenidone)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/208780s007%2C022535s016lbl.pdf

DailyMed – Pirfenidone Tablets, Updated January 2026
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08046b49-a8b3-a78d-e063-6394a90a80fa

MedlinePlus – Pirfenidone Drug Information
https://medlineplus.gov/druginfo/meds/a615008.html

Disclaimer: The medicine information provided on this page is for general knowledge purposes only. It is not intended to replace professional medical advice. Please consult your doctor or pharmacist before using any medicine.
- Grant Pharmacy

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